Effects of tapentadol on mechanical hypersensitivity in rats with ligatures of the infraorbital nerve versus the sciatic nerve.
RatOtherSprague-DawleyMaleIntraperitoneal1 to 10 mg/kgTreatment 2 weeks after nerve constriction surgery
Model: Unilateral chronic constriction injury of the infraorbital nerve or of the sciatic nerve
Acute tapentadol significantly reduced allodynia after both infraorbital and sciatic nerve constriction, its anti-allodynic effect was maintained after 4 days of repeated treatment whereas the effect of morphine vanished, and treatment did not alter nerve lesion-evoked overexpression of activating…
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