Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury.
MouseChemical/toxinC57BL/6Male
Model: Acute wood smoke inhalation exposure in mice, with parallel in vitro exposure of primary human bronchial epithelial cells to wood smoke extract
Acute wood smoke exposure promoted AMPK phosphorylation, macrophage inflammatory protein 2 expression and lung inflammation in mice, all of which were reduced by Compound C treatment. The work positions NADPH oxidase-dependent, reactive oxygen species-sensitive AMPK signalling as the pathway drivin…
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