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PRECLINICAL PUBLICATION · 2012

3,5,4'-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1alpha.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 23219988 ↗2012Reported benefit

3,5,4'-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1alpha.

RatOtherSprague-DawleyMalePretreatment before seawater aspiration

Model: Seawater aspiration (drowning) induced acute lung injury

Pretreatment with different doses of 3,5,4'-tri-O-acetylresveratrol improved seawater-induced lung histopathological changes, alleviated lung oedema, reduced TNF-alpha and IL-1beta, inhibited malondialdehyde and enhanced total superoxide dismutase activity. The protection was associated with inhibi…

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.