A physiological role for connective tissue growth factor in early wound healing.
MouseWoundC57Bl/6 wild-type, plus CTGF haploinsufficient mice and wild-type littermatesn = Sponge time course GFP-MSCs n=18, sFRP2-MSCs n=18, saline n…Local injection into subcutaneously implanted polyvinyl alcohol sponges, and soak loading of sponges before implantationRecombinant CTGF 1 microgram per sponge in 10 microlitres;…Antibody or IgG admixed with MSCs at sponge implantation with injections from 2…
Model: Polyvinyl alcohol sponge (6 mm) implanted in ventral subcutaneous pockets as a granulation tissue model; 6 mm full-thickness excisional dorsal wounds, including a stented cohort with a 10 mm silicone splint; human partial-thickness burn wound margins studied in parallel
Blocking CTGF during the first 7 days reduced the quantity, organisation and vascularity of mesenchymal stem cell derived granulation tissue (31.3 plus or minus 3.8 per cent versus 40 plus or minus 2.3 per cent, p<0.05), supporting a pro-reparative role for early CTGF. Prolonged recombinant CTGF ov…
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