Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice.
MouseTBIUnspecifiedmale1, 3 or 10 mg/kg2 h after traumatic brain injury
Model: Traumatic brain injury induced by mechanical percussion in mice
A single dose of etazolate produced dose-dependent anti-inflammatory and anti-oedematous effects with lasting memory improvement, reduced locomotor hyperactivity and olfactory bulb tissue protection, associated with restored sAPPα levels.
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