RAGE deficiency improves postinjury sciatic nerve regeneration in type 1 diabetic mice.
MouseCrushPeripheral-nerve crushC57BL/6 wild-type and homozygous RAGE-null micemalen = n=9 per group for myelinated fibre histology; n=15 per grou…Germline knockout; bone marrow reconstitution by intraorbital injection; streptozotocin intraperitonealGenetic deletion, no dose. Streptozotocin 50 mg/kg; lethal…RAGE deletion constitutive and present before injury; bone marrow transplantati…
Model: Unilateral sciatic nerve crush performed 2 months after confirmation of streptozotocin-induced type 1 diabetes (streptozotocin 50 mg/kg intraperitoneally for 5 days; blood glucose above 13 mmol/L defined as diabetic)
RAGE deletion, global or restricted to bone marrow, increased myelinated fibre density and motor and sensory conduction velocity after sciatic nerve crush in diabetic mice, with greater M2 macrophage polarisation; no significant benefit was seen in non-diabetic mice.
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