Role of cortical reorganization on the effect of 5-HT pharmacotherapy for spinal cord injury.
RatSpinal cord injuryComplete transectionSprague-DawleyfemaleAcute administration in adulthood, long after neonatal spinal transection
Model: Complete spinal cord transection performed in neonatal rats, studied at adulthood
mCPP increased weight-supported stepping in only a subset of animals, and neurons from responder animals showed greater responsiveness to passive and active forepaw stimulation off-drug than neurons from non-responders, suggesting cortical reorganisation underlies the differential drug response.
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