PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2012

Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 23154884 ↗2012Reported benefit

Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity.

MouseRadiationC57BL/6malen = Placental extract group n=6; control group n=6Oral administration1 mg in 0.2 mL distilled water per mouse per dayGiven soon after each irradiation exposure; mice euthanised 2 days after the la…

Model: Whole-body gamma-ray irradiation at 1 Gy per day for 5 consecutive days from a caesium source at a dose rate of 0.86 Gy/min

Oral placental extract increased bone marrow mononuclear cell number, CD34-positive (0.87 plus or minus 0.07% versus 0.33 plus or minus 0.12%) and c-kit-positive (0.77 plus or minus 0.09% versus 0.26 plus or minus 0.03%) progenitor percentages and colony number (37.1 plus or minus 3.3 versus 20.3 p…

Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.