Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats.
RatChemical/toxinWistarmaleOral administration100, 200 and 400 mg/kg body weightOnce daily for 7 days before carbon tetrachloride challenge
Model: Acute liver injury induced by carbon tetrachloride in rats
Both extracts significantly reduced serum transaminases, alkaline phosphatase and bilirubin, raised total protein and antioxidant enzyme activities, lowered malondialdehyde and improved liver histopathology, with only slight genotoxic effects seen for the root extract.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.