CSF-1 signaling mediates recovery from acute kidney injury.
MouseIschaemia-reperfusionRenalC57BL/6 and transgenic micemaleMacrophage and dendritic cell depletion applied during the recovery phase after…
Model: Acute kidney injury induced by renal ischaemia/reperfusion, and a diphtheria toxin-induced model of selective proximal tubule injury
Depleting macrophages and dendritic cells or blocking CSF-1 signalling increased functional and histological injury, reduced M2 polarisation and delayed recovery, indicating that CSF-1-driven expansion of resident renal macrophages is required for tubule regeneration.
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