Long-term reparative effects of mesenchymal stem cell therapy following neonatal hyperoxia-induced lung injury.
RatOtherSprague-Dawleymale and femaleIntratrachealSingle dose on postnatal day 9, after hyperoxic injury was established
Model: Neonatal hyperoxia-induced lung injury from postnatal day 2 to day 16
Both mesenchymal stem cells and conditioned medium improved alveolar and vascular development at all time points with reduced inflammatory mediator expression, and at postnatal day 100 the improvement was greater with cells than with conditioned medium.
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.