Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.
MouseRadiationWild-type and knockout miceAdministered 24 h after radiation exposure
Model: High-dose gamma-irradiation causing acute radiation syndrome, with in vitro irradiation of mouse embryonic fibroblasts
GRI977143 acted as a radiomitigator, rescuing the lives of mice from otherwise lethal irradiation when given 24 h after exposure and reducing apoptotic signalling in vitro, including bystander apoptosis.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.