Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6 and IL-17A knockout mice
Model: Intestinal ischaemia-reperfusion produced by 30 minutes of superior mesenteric artery occlusion
Genetic deletion of IL-17A or treatment with an IL-17A neutralising antibody markedly reduced intestinal ischaemia-reperfusion injury and subsequent liver and kidney dysfunction, and Paneth cell depletion produced similar protection with lower IL-17A levels.
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