From popular use to pharmacological validation: a study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract.
MixedWoundmaleOral and topical150 to 500 mg/kg orally; topical 1%, 3% and 5%Administered in acute pain, oedema and wound models; topical extract applied to…
Model: Excision wound model in rats, with carrageenan, prostaglandin E2, substance P and bradykinin induced paw oedema, croton oil, arachidonic acid and capsaicin induced ear oedema, carrageenan pleurisy and formalin nociception in mice
Topical 5% extract reduced ear oedema by 70.85 to 78.09% and oral 500 mg/kg reduced paw oedema by 40 to 57%, leucocyte influx by 78%, nitric oxide by 77.77% and TNF-alpha by 50%, inhibited nociception, and topical 5% significantly reduced excision wound area without altering motor performance.
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.