Inhibition of hydrogen sulfide generation contributes to lung injury after experimental orthotopic lung transplantation.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleymaleIntraperitonealNaHS 14 µmol/kg; propargylglycine 37.5 mg/kg15 minutes before the start of lung transplantation
Model: Single left orthotopic lung transplantation after 3 h of cold ischaemia time
NaHS improved pulmonary function and decreased lipid peroxidation, myeloperoxidase activity and interleukin 1β while increasing interleukin 10 in lung grafts, whereas propargylglycine worsened pulmonary function and lung injury.
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