Involvement of the apelin receptor APJ in Fas-induced liver injury.
MouseChemical/toxinICR background; APJ knockout and wild typeMaleIntraperitoneal (Jo2 challenge)Assessment 3 and 6 h after Jo2 injection
Model: Agonistic anti-Fas antibody (clone Jo2) induced acute liver injury
APJ deletion markedly reduced Jo2 induced liver injury and apoptosis and abolished JNK activation; a JNK inhibitor partially reduced injury in wild type mice.
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