Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice.
MouseIschaemia-reperfusionIntestinal / mesentericICRn = 50 mice, five groups of 10IntraperitonealLow dose and high dose groups; numerical doses not stated i…Pretreatment before ischaemia
Model: Superior mesenteric artery occlusion 45 min then reperfusion 90 min, with remote lung injury
Protocatechuic acid pretreatment reduced lung histological injury, lowered TNF-alpha, interleukin 6 and caspase-3, and raised glutathione, MnSOD and Bcl-xL.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.