Evidence of delayed gastrointestinal syndrome in high-dose irradiated mice.
MouseRadiationC57BL/6MaleOral0.67 g per litre in drinking water, also used to wet foodFrom day 4 after irradiation
Model: Partial body X irradiation 8 to 16 Gy with head, forelimbs and thorax shielded, sparing about 40% of bone marrow, 300 kV at 70 cGy per minute
Ciprofloxacin delayed onset and lowered incidence of delayed gastrointestinal effects at 13 to 14 Gy but not above 14 Gy, and reduced weight gain in unirradiated controls.
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