Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals.
MixedChemical/toxinWistar ratsMaleOralBefore ulcer induction for gastroprotection and after induction for healing
Model: Gastric ulcer induced by ethanol, indomethacin and cold restraint stress (acute) and acetic acid (chronic)
The extract was gastroprotective in all three acute models and healed acetic acid ulcers, acting through antioxidant, antisecretory and anti-inflammatory routes.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.