Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleDose dependent effect reported; numerical doses not stated…Applied before, during and after occlusion; also effective when delayed up to 6…
Model: Transient focal cerebral ischaemia by endothelin induced middle cerebral artery occlusion
KN38-7271 gave significant dose dependent and long lasting reduction in cortical lesion size and improved severe motor deficits, including with 6 h delayed dosing.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.