Exercise promotes bone marrow cell survival and recipient reconstitution post-bone marrow transplantation, which is associated with increased survival.
MouseRadiationC57BL/6, with green fluorescent protein labelled donor marrowMale and femaleNot applicableTreadmill running 3 days per week for 8 weeksPreconditioning before transplantation
Model: Myeloablative preconditioning irradiation followed by bone marrow transplantation
Exercise preconditioning raised recipient survival after bone marrow transplantation from 25 to 82 per cent and increased total blood cell reconstitution at 1 and 3.5 months, without altering donor cell homing or donor-derived engraftment.
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