Functional assessment of the acute local and distal transplantation of human neural stem cells after spinal cord injury.
RatSpinal cord injuryContusionLong-Evans hoodedFemalen = 24 rats, 6 per group across four groupsSubdural injection at the injury site, or intrathecal injection via a separate distal laminotomyAcute, at the time of injury
Model: Moderate T10 spinal cord contusion using the Multicenter Animal Spinal Cord Injury Study impactor, 10 g weight dropped from 25 mm after laminectomy
Both local subdural and distal intrathecal transplantation of human fetal neural stem cells significantly improved Basso, Beattie and Bresnahan locomotor scores compared with media controls at p=0.034 and p=0.016 respectively, with no difference between the two routes.
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