Recombinant human MFG-E8 attenuates intestinal injury and mortality in severe whole body irradiation in rats.
RatRadiationSprague-DawleyMalen = Histology and morphometry n=4 per group; MFG-E8 gene expres…Subcutaneous166 micrograms/kg body weight in vivo; 0.5 micrograms/mL in…First dose 6 h after whole body irradiation; in vitro 1 h before and immediatel…
Model: Whole body irradiation at 10 Gy from a Cesium-137 source delivered at approximately 2.5 Gy/min over 4 min, previously determined as the dose lethal to 70 per cent of animals at 21 days; in vitro IEC-6 rat small intestinal epithelial cells irradiated at 8 Gy
Subcutaneous rhMFG-E8 started 6 h after 10 Gy whole body irradiation improved 21-day survival from 31 to 75 per cent and reduced the radiation injury intestinal mucosal damage score by 36 per cent, with increased p53, p21 and Bcl-2 expression.
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