Purinergic 2Y1 receptor stimulation decreases cerebral edema and reactive gliosis in a traumatic brain injury model.
MouseTBIClosed-head / concussionC57BL/6; inositol 1,4,5-trisphosphate receptor type 2 knockout100 micromolar 2MeSADP or 100 micromolar MRS236530 min after trauma
Model: Controlled closed head injury using a pneumatic impact device
Treatment with 2MeSADP or MRS2365 30 min after closed head injury reduced oedema, neuronal swelling, reactive gliosis and aquaporin 4 expression, and the protective effect was lost in inositol 1,4,5-trisphosphate receptor type 2 knockout mice.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.