Prostacyclin reduces plasma volume loss after skeletal muscle trauma in the rat.
RatCrushLimb / muscle crushSprague-DawleyMaleInfusion2 ng/kg per minuteStarted after the trauma
Model: Controlled standardised blunt trauma to the abdominal rectus muscle in anaesthetised animals
Prostacyclin limited the fall in plasma volume 3 h after blunt muscle trauma to 11 per cent compared with 22 per cent in saline treated animals and lowered interleukin 6, while the transcapillary escape rate for albumin did not differ significantly.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.