The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury.
RatSpinal cord injuryContusionFischerFemalen = 337 rats in total, 318 analysed after 19 attrition or exclu…Subcutaneous for dose finding; oral, subcutaneous and intravenous compared in the route study; intravenous via jugular catheter for the therapeutic window, biochemical and behavioural studies0.1, 0.5, 1.0 or 5.0 mg/kg in the dose-finding study, with…1 h after injury for the dose-finding and route studies; therapeutic window stu…
Model: Moderate thoracic contusion spinal cord injury at T8 using the MASCIS impactor, 10.0 g rod dropped from 12.5 mm after laminectomy with the dura intact
Rolipram at 1.0 mg/kg once daily for two weeks preserved neurons, oligodendrocytes and central myelinated axons by the oral, subcutaneous or intravenous routes and improved Basso, Beattie and Bresnahan locomotor scores from 4 to 6 weeks, with neuronal protection retained when treatment started up t…
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