Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A.
RatTBIFluid percussionSprague-DawleyMaleIntracerebral microinjectionAfter fluid percussion injury
Model: Unilateral fluid percussion injury of moderate severity at 2.2 to 2.5 atmospheres
Adenoviral VEGF zinc-finger protein reduced TUNEL-positive cells in the cortical penumbra and hippocampus at 72 h and improved CA1 field excitatory postsynaptic potentials, while adeno-associated vector delivery improved microvascular diameter and balance beam and rotarod performance at 30 days.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.