Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)Male and femaleIntrahippocampal viral gene transferBefore hypoxia-ischaemia
Model: Neonatal hypoxia-ischaemia; in vitro apoptosis induced by staurosporine or C2-ceramide
Viral delivery of Bcl-x(S) short hairpin RNA into the rat hippocampus before neonatal hypoxia-ischaemia decreased vulnerability to brain injury, consistent with in vitro attenuation of apoptosis by Bcl-x(S) knockdown.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.