Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntracerebroventricular1, 10 or 100 ng30 min before middle cerebral artery occlusion
Model: Transient focal cerebral ischaemia by 30 min middle cerebral artery occlusion followed by 24 h reperfusion
HAMI 3379 at 10 and 100 ng, but not 1 ng, attenuated neurological deficits and reduced infarct volume, brain oedema, IgG exudation, neuronal degeneration and neuronal loss, to an extent similar to pranlukast.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.