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PRECLINICAL PUBLICATION · 2012

miR-124 regulates neural stem cells in the treatment of spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 22999930 ↗2012Reported benefit

miR-124 regulates neural stem cells in the treatment of spinal cord injury.

RatSpinal cord injuryUnspecifiedWistarIntravenous injectionAfter spinal cord injury (acute phase; exact interval not stated)

Model: Experimental spinal cord injury in rats (model details not specified in the abstract)

Intravenous delivery of miR-124-transfected neural stem cells increased neuronal differentiation, reduced astrocytic differentiation, reduced lesion cavity volume and produced better functional recovery than untransfected neural stem cells or sham controls.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.