Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor.
RatChemical/toxinWistarMalen = Minimum of 3 to 4 animals per treatment groupIntraperitoneal50 mg/kgBeginning one hour before nitrogen mustard exposure
Model: Intratracheal instillation of nitrogen mustard (mechlorethamine) 0.125 mg/kg
Aminoguanidine abrogated nitrogen mustard-induced injury, oxidative stress and inflammation at 1 and 3 days post exposure, but had no effect at 7 or 28 days and did not prevent pulmonary fibrosis.
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