Ameliorative potential of alpha-ketoglutaric acid (AKG) on acute lung injuries induced by ammonia inhalation in rats.
RatChemical/toxinSprague-DawleyMaleInhalation by nebulisation5% alpha-ketoglutarate respiratory fluidAfter ammonia exposure
Model: Inhalation of aerosolised liquid ammonia producing acute lung injury
Alpha-ketoglutarate inhalation lowered bronchoalveolar lavage total cell count, total protein, lactate dehydrogenase, superoxide dismutase and malondialdehyde, and increased catalase and glutathione, with corresponding improvement in lung histopathology.
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