Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats.
RatTBIFluid percussionSprague-DawleyMaleIntravenous500 microgramsImmediately after the onset of fluid percussion injury
Model: Lateral fluid percussion traumatic brain injury
Secretome therapy significantly attenuated motor deficits and cerebral infarction, reduced neuronal loss and apoptosis, and increased VEGF-positive cells in the injured cortex.
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