Parstatin prevents renal injury following ischemia/reperfusion and radiocontrast administration.
MixedIschaemia-reperfusionRenalWistar (rats)MaleSystemic administration15 min before or immediately after renal ischaemia; single dose before inductio…
Model: Bilateral occlusion of renal arteries and veins for 45 min followed by 4 h reperfusion in rats, and intravenous iopromide radiocontrast in rabbits
Parstatin attenuated renal dysfunction and histological injury in both models in a dose-dependent manner, with more prominent protection of tubular than glomerular function.
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