Phenylephrine-induced hypertension during transient middle cerebral artery occlusion alleviates ischemic brain injury in spontaneously hypertensive rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Spontaneously hypertensive ratMalen = n=6 per group (12 rats)Intravenous (tail vein)15-20 micrograms/kg/min titrated to mean arterial pressure…Throughout the 1 h occlusion, discontinued after reperfusion
Model: Transient (1 h) middle cerebral artery occlusion
Maintaining pre-existing hypertension significantly reduced infarct volume, oedema and neurological deficits, with higher and more rapidly restored regional cerebral blood flow.
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