Analysis of minocycline as a countermeasure against acute radiation syndrome.
MouseRadiationC57BL/6FemaleIntraperitonealBeginning immediately before irradiation
Model: Whole-body irradiation with 1-3 Gy cobalt-60 gamma rays
Minocycline increased splenic macrophages, granulocytes, natural killer, T and CD8+ T cells, raised IL-1alpha, IL-1beta, GM-CSF and G-CSF, and suppressed MIP-1alpha, TNF-alpha and interferon-gamma compared with radiation alone.
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