Passive immunization with tenascin-R (TN-R) polyclonal antibody promotes axonal regeneration and functional recovery after spinal cord injury in rats.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleLocal administration into the lesion site
Model: Spinal cord dorsal hemisection transecting the corticospinal tract
The tenascin-R polyclonal antibody promoted neurite outgrowth and sprouting on inhibitory tenascin-R substrate in vitro, and after local administration into dorsal hemisection lesions significantly decreased RhoA activation and improved functional recovery from corticospinal tract transection.
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