Comparison of the wound healing effect of cellulose and gelatin: an in vivo study.
MouseWoundn = 30 mice divided into control, cellulose and gelatin groupsTopical application into the muscle defectApplied at the time of defect creation
Model: 1 x 1 cm surgical defect created in the rectus abdominis muscle of white mice under anaesthesia with intraperitoneal pentobarbital sodium 40 mg/kg and ketamine hydrochloride 20 mg/kg
At 3 days cellulose showed limited granulation with acute inflammation similar to control, and by 28 days moderate granulation tissue with milder inflammation than control. Gelatin remnants were surrounded by severe inflammatory change at 3 days and the same quantity of remnants persisted at 28 day…
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