Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis.
RatIschaemia-reperfusionHepaticSprague-DawleyMaleAcute administration in the setting of ischaemia/reperfusion liver injury; fasu…
Model: Hepatic ischaemia/reperfusion injury in rats with nonalcoholic steatohepatitis
Acute sorafenib significantly attenuated hepatic inflammation, necrosis, apoptosis, leukocyte infiltration and microcirculatory dysfunction, with reduced macrophage inflammatory protein 2, keratinocyte chemoattractant and GM-CSF release, reduced caspase-3 and caspase-9 and DNA fragmentation, and de…
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