Similar effects of hypertonic saline and mannitol on the inflammation of the blood-brain barrier microcirculation after brain injury in a mouse model.
MouseTBIUnspecifiedCD1MaleIntravenousSingle equiosmolar dose of 20% mannitol or 5% hypertonic sa…After injury
Model: Simulated traumatic brain injury by craniotomy with local suffusion of the brain surface with interleukin 1 beta (100 ng/0.1 mL), with intravital microscopy of pial venules
Neither osmotherapy produced significant differences in neutrophil rolling or adhesion or in vessel permeability, although both trended higher with hypertonic saline; brain and lung oedema were greater with mannitol than with hypertonic saline compared with controls (p = 0.05). The two agents had i…
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