Amniotic-fluid-derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failure.
RatChemical/toxinSprague-Dawley (syngeneic S-D rats)Malen = 15 rats per group for the survival study (4 groups); n = 5…Portal vein transfusion via 28-gauge needle over 5 minutesCell dose reported as 1x10(n) MSCs in a volume of 0.8 mL; e…One day (24 h) after induction of fulminant hepatic failure
Model: Fulminant hepatic failure induced by intraperitoneal injection of D-galactosamine 1.5 g/kg plus lipopolysaccharide 200 ug/kg
21-day survival was 69.2% with IL-1Ra/MSCs and 63.6% with Lv/IL-1Ra versus 22.2% with physiological saline and 30.0% with GFP/MSCs (p < 0.05). IL-1Ra/MSC rats had lower serum ALT on day 5 (448.7 +/- 112.6 versus 657.3 +/- 147.4 IU/L) and day 7 (215.7 +/- 78.3 versus 435.8 +/- 122.7 IU/L), higher Br…
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