Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntraperitoneal7.5 or 15 mg/kg/dayFirst dose 2 h after MCAO surgery
Model: Focal cerebral ischaemia induced by permanent middle cerebral artery occlusion (MCAO)
Leonurine significantly alleviated neurological deficit and decreased brain water content and infarct volume after ischaemic stroke, accompanied by decreased MDA and Bax, increased SOD, CAT, UCP4 and Bcl-2, and restored mitochondrial ultrastructure. Quantitative effect sizes were not reported in th…
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