The biomechanical and histologic effects of platelet-rich plasma on rat rotator cuff repairs.
RatWoundinbred Fischer 344malen = 105 inbred Fischer 344 male rats used in total (90 operated…local application, pipetted onto the tendon-to-bone repair site20 microlitre aliquot of platelet-rich plasma at 3.0 to 5.8…immediately at the time of surgical repair, before wound closure
Model: surgically created supraspinatus tendon detachment from its humeral footprint with immediate transosseous repair
Platelet-rich plasma did not change failure load at 7, 14 or 21 days. At 7 days the control group had higher failure strain (0.50 vs 0.29 mm/mm, P = .02) and the platelet-rich plasma group showed increased focal fibrinoid necrosis. At 21 days the control group had higher stiffness (12.89 vs 8.99 N/…
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