Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleIntraperitoneal injection (intermittent dosing) or continuous infusion via an implanted infusion pumpIntermittent regimen: 1 h before ischaemia and 1 h and 6 h after the start of r…
Model: Transient focal cerebral ischaemia (1 h middle cerebral artery occlusion) followed by 24 or 72 h of reperfusion
ATK given 1 h before ischaemia and at 1 h and 6 h of reperfusion significantly reduced striatal and hemispheric infarct volume at 24 h, and continuous infusion significantly reduced cortical and whole hemispheric infarct volume at 72 h. No protection was seen when dosing began after ischaemia onset…
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