Synergistic protection against hyperoxia-induced lung injury by neutrophils blockade and EC-SOD overexpression.
MouseOtherB6C3 background; transgenic mice carrying an extra copy of human EC-SOD under the SP-C promoter, and wild type littermatesn = 10 pups per group across 8 groups; 5 animals per group used…Intraperitoneal injectionAntileukinate 100 microgram/g body weight in 0.1 ml 0.9% w/…First dose given at birth as soon as litters were born, before the start of hyp…
Model: Hyperoxia-induced neonatal lung injury (95% FiO2 for 7 days from birth), compared with room air
Antileukinate significantly reduced bronchoalveolar neutrophil counts, myeloperoxidase activity, albumin leak and 8-isoprostane, and increased the reduced to oxidised glutathione ratio in both wild type and transgenic pups after hyperoxia. Antileukinate-treated transgenic pups showed significantly…
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