Plerixafor, a CXCR4 antagonist, mitigates skin radiation-induced injury in mice.
MouseRadiationC57BL/6Intraperitoneal5 mg/kgAdministration started on day 0, 4, 7, 15 or 24 after irradiation, with maximum…
Model: Radiation-induced skin injury produced by irradiation of the right hind leg; a 30 Gy exposure was used for the SDF-1 time-course measurements
Plerixafor improved both acute and late skin radiation responses, with the effect strongly dependent on timing of administration. Maximum benefit occurred when dosing started 1 week after irradiation, while earlier or later administration reduced efficacy. Cytokine levels and histologically assesse…
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