MRI measurement of angiogenesis and the therapeutic effect of acute marrow stromal cell administration on traumatic brain injury.
RatTBIControlled cortical impactWistarMalen = n = 18 total; saline n = 9, hMSC n = 9Intravenous injection3 x 10(6) hMSCs in 1 mL suspension6 hours after traumatic brain injury
Model: Controlled cortical impact traumatic brain injury
Transplantation of hMSCs 6 hours after injury reduced cerebral atrophy, produced earlier and enhanced cerebral tissue perfusion, increased angiogenesis and improved functional outcome relative to saline controls.
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