Effect of safflor yellow injection on inhibiting lipopolysaccharide-induced pulmonary inflammatory injury in mice.
MouseEndotoxin/LPSMalen = 72 mice divided into six groupsIntravenous10, 20 or 40 mg/kg30 minutes before lipopolysaccharide administration
Model: Acute lung injury induced by intraperitoneal lipopolysaccharide 15 mg/kg
Safflor Yellow Injection mitigated the lipopolysaccharide-induced rise in PaCO2 and falls in PaO2, SO2 and pH, attenuated lung water content index and myeloperoxidase activity, reduced NF-kappaB p65 staining and TNF-alpha, IL-1beta and IL-6 mRNA, increased IL-10 and suppressed p38 MAPK phosphorylat…
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