Bone marrow-derived mesenchymal stromal cells and platelet-rich plasma on a collagen matrix to improve fascial healing.
RatWoundLewisMalen = 42 Lewis rats across three groupsLocal overlay of the collagen matrix on the primary fascial repairAt the time of laparotomy repair
Model: Midline laparotomy with primary fascial repair, as a model of incisional hernia formation
At 4 weeks tensile strength doubled with matrix and platelet-rich plasma and quadrupled with added stromal cells versus primary repair alone (p less than 0.001). Total energy absorption rose 320 per cent at 4 weeks and 142 per cent at 8 weeks in the cell group, with significantly increased vascular…
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