PRECLINICAL PUBLICATION · 2012

Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

Mouse / Chemical/toxin

Evidence by therapy association

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Hepatocyte-specific genetic ablation of spermine/spermidine-N1-acetyltransferase (SSAT); separately, pharmacological inhibition of polyamine oxidases

PMID 22723264 ↗2012Mixed findings

Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

MouseChemical/toxinHepatocyte-specific SSAT knockout (Hep-SSAT-Cko) and wild-type mice

Model: Carbon tetrachloride (CCl4) induced acute toxic liver injury

Early liver injury after CCl4 was significantly attenuated in hepatocyte-specific SSAT knockout mice, with lower serum alanine aminotransferase, less hepatic lipid peroxidation and less severe histological damage, and polyamine oxidase inhibition was also protective. However, the onset of hepatocyt…

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